Genetic studies of diseases

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postnatal studies of bats (pipistrellus kuhlii and miniopterus schreibersii) & histomorphology and histochemistry studies of organs and diseases of (neurergus microspilotus and n. kaiseri)

1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...

Strategies for Genetic Studies of Complex Diseases

In light of this, it is likely that GWAS hits found in intergenic regions far from known genes are true associations whose biology is not yet understood, rather than false positives. The human genome is incompletely annotated. Regions where GWAS associations have been found, but no known genes are located, could easily harbor unidentified new genes or regulatory elements. For instance, the auth...

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Genetic Studies in Human Prion Diseases

Human prion diseases are fatal neurodegenerative disorders that are characterized by spongiform changes, astrogliosis, and the accumulation of an abnormal prion protein (PrP(Sc)). Approximately 10%-15% of human prion diseases are familial variants that are caused by pathogenic mutations in the prion protein gene (PRNP). Point mutations or the insertions of one or more copies of a 24 bp repeat a...

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The future of genetic studies of complex human diseases.

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ژورنال

عنوان ژورنال: Cellular and Molecular Life Sciences

سال: 2007

ISSN: 1420-682X,1420-9071

DOI: 10.1007/s00018-007-7057-3